- Current oncology clinical trials , Assistant Research Physician in the Center for Immuno-Oncology, is researching immunotherapy for adults with advanced solid tumors. Clinical trials are important in developing new treatments for serious diseases like cancer. Polypharmacy is highly prevalent among adults with cancer and multimorbidity, and is associated with high health service utilization even among younger adults. Cancer clinical trials can take years to complete. Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cell therapy (ACT), which collects infiltrating lymphocytes at the tumor site and expands them in vitro to obtain TIL final products cloned Digital clinical trials: Creating a vision for the future. A toxicity-based dose reduction algorithm is commonly implemented in clinical trials in oncology. Clinical trials are part of clinical research and at the heart of all medical advances. , Scottsdale/Phoenix, Ariz. Cancer ranks as a leading cause of death and an important barrier to increasing life expectancy globally, accounting for nearly 10 million deaths in 2020. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. For example, when a promising new therapy is being studied in early-stage clinical trials for cancer with high unmet needs, enrolling patients into control arms may cause ethical issues and unwillingness to participate[2]. The trial will explore if the Cytosponge, a ‘sponge-on-a-string' test for Barrett’s oesophagus developed by Fitzgerald, can prevent deaths from oesophageal cancer when offered as a screening test to people on long-term medication for heartburn – one of the most common Barrett’s oesophagus symptoms. Clinical Trial Resources. cancer therapeutic research has largely shifted from a focus on cytotoxic agents to newer drugs that act through inhibiting cancer cell growth and survival mechanisms while protecting healthy cells to the extent possible . Phase II clinical trials test the safety and effectiveness of an investigational treatment, in this case stereotactic radiation, to learn whether this treatment works in treating a specific disease. 1038/s41746-019-0203-0 [PMC free article] [Google Scholar] Thompson MA, & O’Regan R. Rochester, Minn. Find an NCI-supported clinical trial—and learn how to locate other research studies—that may be right for you or a loved one. com electronic databases, as well as for abstracts from the meetings of the American Society of Clinical Oncology, American Society of Hematology, American Association for Cancer Research, and European Society for Clinical Oncology, all from Clinical trial design. To help you decide, ask your care team: The trial protocol is a detailed plan that a clinical trial follows. Clinical trials are scientific studies that involve people in research and are the only way to advance cancer treatment. Phase 0, window of opportunity, and adaptive designs have been proposed, but their advanced methodologies and underlying biostatistics are not widely known. For the trend analysis of the number of trial registrations over time, the APC of the number of trial registrations showed two periods, both of which showed continuous upward trends (2008–2010: APC = 761. In Cambridge, Professor Rebecca Fitzgerald is running a trial called BEST4. They help us find better ways to prevent, diagnose, and treat cancer. Amidst this renewed focus on diversity, it is crucial to acknowledge that Asia comprises over half of the world’s population. We look forward to your contributions Participation in clinical trials can benefit not only you, but future cancer patients as well. 25 studies in Radiation Oncology (open studies only). NPJ Digital Medicine, 2, 126. Over 13,000 Illinois CancerCare patients have participated in such trials. Oct 28, 2022 · 1 EARLY PHASE ONCOLOGY CLINICAL TRIALS IN ASIA. For example, when a promising new therapy is being studied in early-stage clinical trials for cancer with high unmet needs, enrolling patients into control arms may cause ethical issues and unwillingness to participate [2]. 439 studies in Cancer (open studies only). View Clinical Trials Jul 30, 2024 · Immunotherapies, mainly immune checkpoint inhibitors (ICIs), have revolutionized cancer treatment strategies over the past decade, but their limitations have limited clinical applications. Existing research has highlighted a significant demographic imbalance. In this section you can learn about clinical trials in general, find tools to help you decide if a clinical trial may be right for you, and search for specific studies you may be eligible for. Availability and representation of race and ethnicity data by trial funding type, temporal May 11, 2021 · In conclusion, the lack of diversity in cancer clinical trials remains a major scientific challenge. In fact, it's recommended that you seek out a clinical trial as soon as you're diagnosed. Many cancer centers across the United States, including NCI-Designated Cancer Centers, sponsor or take part in cancer clinical trials. If you would like more information about a clinical trial, please contact of our research Clinical trials are research studies that evaluate a new drug or treatment to make sure that it is safe and effective for patients. A clinical trial led by Danielle M. “Clinical trials are essential to be able to identify better treatments for patients with all tumor types,” says Funda Meric-Bernstam, M. 4,12 Biopsies necessary to apply companion About Clinical Trials. Clinical trials and the people who volunteer for them help shape the future of medicine. Here is a list of the trials currently available for enrollment. Feb 24, 2025 · AI applications in clinical research are primarily concentrated in oncology, especially in patient recruitment — one of the most challenging aspects of clinical trials. Dec 24, 2024 · Below are current clinical trials. Current clinical trials | College of Veterinary Medicine May 29, 2024 · 1621Background: While accounting for 40% of the cancer population, older adults are underrepresented in clinical trials. 2 per 100,000 individuals). More than 700 companies are involved. 1-3 Factors cited for globalization of cancer clinical trials include the ability to reduce operational costs, access to treatment-naïve patients, growth of the health care market size, the Review Lilly's oncology pipeline to see the current clinical trials for cancer patients, and to see whether or not we are accepting enrollments Trial Spotlight Dec 8, 2023 · Introduction There has been a growing recognition on the importance of diversity in clinical trials. The research trials conducted by our faculty include radiation therapy, radiation therapy combined with chemotherapy agents, devices, imaging studies, supportive care, quality of life and tissue/blood sampling research. Jul 25, 2019 · With improved molecular understanding of cancer and the growth of precision medicine, the use of biopsies to evaluate biomarkers has become common in clinical trials. Learn More Over the past decades, there has been an expansion of cancer clinical trials from resource rich-countries to involve other countries with lesser resources. MD Anderson uses clinical trials to prevent, diagnose and treat cancer. Search for clinical trials here and also learn about the different phases. gov. Given the region’s demographic significance, we sought to compare various characteristics and The new draft guidance, “Considerations for Generating Clinical Evidence from Oncology Multiregional Clinical Development Programs,” expands on current principles for MRCTs and, when finalized Paediatric cancer studies are research studies/trials that affect children, adolescents, and young adults. 3 days ago · Access these engaging slides created by a breast oncology expert to learn about the latest indications, clinical evidence, and real-world data with the ADCs for breast cancer care. The author provides a simple framework to help researchers ensure the ethical integrity of a clinical trial in oncology. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early-phase programs, a Society for Neuro-Oncology Think Tank was held in November 2020 to prioritize areas for improvement in the conduct of glioblastoma clinical trials. We have many opportunities for pet animals to participate in clinical trials. Each listing below has a quick summary plus a link to more information for each study. 7%) were driven in small cohort sizes, median=100 (range 1–99,481). Click on a cancer type from the drop-down menu and either click through the chart based upon the type of trial or view the entire flowchart at once. Established in 1994, the journal represents a multidisciplinary medium for clinical oncologists to report and review progress in the management of this disease. It can take months, if not years, to see if a cancer treatment does what it is meant We identified 1370 clinical trials (FDA = 1129, EMA = 241) involving liquid-biopsy analysis in cancer. 1 million NCORP award is the single largest grant ever extended by the NCI for clinical cancer research and cancer clinical trials in the state of Maine. May 10, 2024 · In this work, Unger et al 6 examine the rates of clinical trial enrollment using the data from the Commission on Cancer, 7 with a goal of generating a better understanding of current trends in cancer clinical trial enrollment. Dec 1, 2024 · A cooperative oncology group that designs and administers clinical trials in cancer therapy, supportive care, and prevention across Canada. We are nationwide leaders in clinical oncology trials and research, and our oncologists have been involved in hundreds of trials that have led to some of the most effective treatments available today. Through this funding, MaineHealth Cancer Care Network Lifespan Program was establishe May 16, 2024 · Cancer centers and clinics that conduct cancer clinical trials. The University of Missouri Veterinary Medical Center is enrolling patients into a clinical trial evaluating the safety and effectiveness of a new immunotherapy, the Vaccine Peptide Library (VPL), when given to dogs with cancer. 001; 2010–2021: APC = 9. The indication being investigated in the highest number of trials was gastrointestinal cancer, accounting for ~24% of indications in 2022 trials and ~23% in 2023 trials (Figure 2). We look forward to your contributions Access cutting-edge cancer treatments. doi: 10. A clinical trial is an option at any stage of your cancer journey. According to WCG’s 2024 Clinical Research Site Challenges Report, a common hurdle is the need for improved communication and streamlined collaboration between sponsors and sites. Apr 19, 2022 · Oncology clinical trial starts reached historically high levels in 2020, up 60% from 2015, and focused mostly on rare cancer indications. Jan 22, 2025 · The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. Doctors use clinical trials to develop new treatments for serious diseases such as cancer. Jan 4, 2024 · Detailed trial phases of the 7747 clinical trials on cancer. "Investigational" means that the treatment is being studied. Arena International are delighted to announce 11th Annual Clinical Trials in Oncology Europe will be returning to Munich on 26-27 November 2025! The programme will, through a variety of interactive session formats, offer insight on promoting successful collaboration between the clinical trials community and once again offer attendees practical take-aways that they can apply to […] As a leading research institution, Duke Radiation Oncology fields numerous clinical trials across all cancer sites. Read More Clinical trial researching combination drug therapy for neuroendocrine carcinomas Current Clinical Trials. Dec 1, 2020 · The way Oncology clinical trials are designed and performed has changed over time. Released: March 13, 2025 Sep 9, 2016 · H&O Do clinical trials in oncology have a high rate of dose reductions? NR Trials of chemotherapeutic agents typically start with a maximum tolerated dose that may be lowered for some patients based on tolerability and response. 4 per 100,000 individuals), and its mortality rates are low (63. Concurrently randomized control arms allow for an understanding of the temporally relevant factors associated with the natural history of the disease, particularly with respect to current standards of clinical care. Phase 1/2 Study of MRTX1719 in Solid Tumors With MTAP Deletion. These fusions lead to pathophysiologic activation of HER signaling pathways, promoting tumor growth, invasion, and metastasis. This review focuses on statistical considerations in the design and analysis of oncology clinical trials. Map source: Community oncology and prevention trials research group, Division of Cancer Prevention, NCORP, 2019 . 4,10 Biopsies may be used to identify prognostic and predictive biomarkers, provide insight into mechanisms of drug response and resistance, and inform the development of new agents. Studies in dogs with cancer will complement current human trials designed to test new doses and effects of this agent. Jul 4, 2023 · Purpose of Review Innovative clinical trial designs for glioblastoma (GBM) are needed to expedite drug discovery. Most people who take part in clinical trials hear about them from their doctors. S. Aug 7, 2020 · PURPOSE Adequate clinical services have yet to be established in the majority of African countries, where childhood cancer survival rates vary from 8. Clinical trials are the only way new cancer treatments can be tested for success and safety before being made available to the public. Clinical Trial Flowcharts are maps to help you find University of Illinois Cancer Center clinical trials available for specific types of cancers. Therapeutic advances for glioblastoma have been minimal over the past 2 decades. This review summarizes phase 0, window of opportunity, and adaptive phase I–III clinical trial designs in GBM tailored to Nov 28, 2020 · Current Oncology is committed to being recognized as an outstanding clinical oncology journal with rigorous peer review and an efficient publication process. Clinical trials look at new ways to prevent, detect, or treat disease. 1 The overall burden of cancer incidence and mortality is growing rapidly, and this reflects both aging and growth of the population as well as changes in the prevalence and distribution of the Historically, the majority of oncology clinical trials are conducted in Western Europe and North America. clinical trials and should require scientific justification for limited or selected study population enrollment. , chair of Investigational Cancer Therapeutics. Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. Most medications and medical devices being used today began in clinical trials to test their safety and effectiveness. 1 The overall burden of cancer incidence and mortality is growing rapidly, and this reflects both aging and growth of the population as well as changes in the prevalence and distribution of the Thoracic Cancer MSK 22-133. In third place in terms of the number of cancer clinical trials is Mexico, with 751 cancer clinical trials and 142 publications; however, the incidence rates are not among the highest in the region (140. The six-year, $5. Methods: The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials. You don't have to wait until other treatments have failed to enroll in a trial. The ideal Jan 31, 2025 · Purpose of Review Neuregulin 1 (NRG1) fusions are rare but actionable oncogenic drivers that occur in a variety of tumor types, including non-small cell lung cancer (NSCLC). Filter this list of studies by location, status and more. 13,14 Furthermore, when evaluated by value scales (eg, the European Society for Medical Oncology Magnitude of Clinical Benefit Scale, only one-third of single-arm "Steps to Find a Clinical Trial" The basics on clinical trials, also from the NCI; Cancer. It means to enroll more Black Americans in cancer clinical trials to try to eliminate the sampling bias. The format is "NCT" followed by an 8-digit number (for example, NCT00000419). To learn more, contact the center’s research nurse at 609. Efforts to increase the efficiency and interpretability of clinical trials within the neuro-oncology community have focused on standardization of response assessment, development of consensus guidelines for clinical trial conduct, decentralization of An increased incidence of cancer in the world has led to an increase in oncology research and in the number of oncology trials. Jan 9, 2022 · The control arm of a randomized clinical trial plays a fundamental role in estimating the efficacy and safety of an investigational therapy. Oncology clinical trials were distributed across 20 indications. Older-age-selected studies are desirable, but their characteristics and overall performance are unknown. First, 64 of 1129 FDA trials (5. It describes the goal, who is eligible to take part, participant protections, details about any testing, procedures, and treatments, the length of the trial, and what information will be collected. Clinical trials are scientific studies in which new treatments – drugs, diagnostic procedures, and other therapies – are tested in patients to determine if they are safe and effective. Following is a listing of clinical trials currently available at Illinois CancerCare. 6786. Clinical trials are research studies in which patients can choose to participate. Current evidence suggests that NRG1 fusion-positive NSCLC does not respond well to conventional Nov 1, 2016 · We searched for these published articles in the Medline, Embase, Clinicaltrials. At any given time, Huntsman Cancer Institute has more than 300 cancer clinical trials open to patients. For details of all paediatric studies available in Ireland, please refer to (opens in a new window) Cancer Trials Ireland. 1 This consultation must reflect on the extraordinary role played by the UK research community in responding to COVID-19—a response enabled by clinical research delivery infrastructure embedded within the National Health Service (NHS), which allowed rapid clinical Sep 27, 2024 · Honoraria: WebMD/Medscape (less than $10,000 USD in a single calendar year), MJH Associates (less than $10,000 USD in a single calendar year), Clinical Care Options (less than $10,000 USD in a single calendar year), Cancer Expert Now (less than $10,000 USD in a single calendar year), Clinical Care Options (less than $10,000 USD in a single calendar year) Doctors use clinical trials to develop new treatments for serious diseases such as cancer. 3%. Although results of nonrandomized clinical trials are markers of drug activity, many drugs approved on the basis of these trials exaggerate treatment efficacy when tested in RCTs. The oncology community is obligated to improve participation of Black Americans in cancer clinical trials. 02, P < 0. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early-phase programs, a Society for Neuro-Oncology Think Tank was held in November 2020 to prioritize areas for improvement in the conduct of glioblastoma clinical Feb 15, 2022 · Abstract. We are a leading protocol organizations within the National Clinical Trials Network and we seek to improve the lives of cancer patients by conducting practice-changing, multi-institutional clinical and translational research. Before people are given a new intervention, it is carefully studied in the laboratory. On behalf of the Editorial Board and team, I welcome you to Current Oncology and encourage you to submit your original research works to the journal. Hundreds of new and promising cancer immunotherapy treatments are only available to patients in clinical trials. The unique identification code given to each clinical study upon registration at ClinicalTrials. FOXFIRE: An open-label randomised phase III trial of 5-Fluorouracil, OXaliplatin and Folinic acid +/- Interventional Radio-Embolisation as first line treatment for patients with unresectable liver-only or liver-predominant metastatic colorectal cancer Our clinical trials aim to find out if a new treatment or procedure is safe, is better than the current treatment or helps you feel better. Nearly all current cancer treatments started in a clinical trial. These clinical trials show promising results for the early detection of cancer and confirm cfDNA as a tool for real-time monitoring of acquired therapy resistance, accurate disease-progression surveillance and improvement of treatment Aug 7, 2020 · The study includes data from the International Pediatric Oncology Society (SIOP) global mapping survey, meta-research identifying trials in Africa in ClinicalTrials. The below videos and tools can assist you as you research clinical trials. Research is the reason more people than ever are beating Clinical trials test the safety and effectiveness of new cancer drugs and treatments. gov Registry of By participating in clinical trials and research studies, participants help advance what is known about medical interventions and cancer risks Penn Medicine Princeton Cancer Center provides the opportunity for patients to enroll in a number of clinical trials. People with cancer can also look for clinical trials online or in other places to find more options for treatment. (2018). The purpose of the study is to describe the p … May 7, 2024 · Below are current clinical trials. Studies with the most promising results are then moved into clinical trials with people. O. This research study is a Phase II clinical trial. Well designed oncology clinical trials are a key part of developing effective anti-cancer drugs. Often, the best new information about cancer comes from animals participating in a clinical trial. Pastor, D. Jan 22, 2024 · Gastrointestinal Cancer Persists as a Leading Oncology Indication. D. Most of the trials analysed have key aspects that can be improved. But you don’t have to wait for your doctor to bring up a clinical trial. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early-phase programs, a Society for Neuro-Oncology Think Tank was held in November 2020 to prioritize areas for improvement in the conduct of glioblastoma clinical In addition, our partnership with the National Cancer Institute (NCI), the Nevada Cancer Research Foundation, and the Children’s Oncology Group (COG) provides Renown with access to dozens of open oncology clinical trials, including ground-breaking treatments for many childhood cancers, studies to better understand these diseases, and trials Mar 1, 2023 · Nevertheless, ethical or feasibility issues can hinder the randomization process in oncology clinical trials. Clinical trials include both observational and interventional studies and cover a broad range of cancer types and therapeutic interventions, with particular expertise in conducting early phase I studies, immunotherapy and cellular therapeutics. Whether to apply to take part in a clinical trial is up to you. Solid Tumors MARCH 12, 2025 May 24, 2022 · For the current study, a clinically significant improvement in survival was conservatively defined as 2 months or more of improvement over the control arm, which is much lower than the 4 to 5 months of survival benefit recommended by the American Society of Clinical Oncology Cancer Research Committee. Help Our Cause. gov, and a literature overview of publications on the subject of pediatric oncology clinical research supported by expert opinions on the current situation and challenges. Below are current clinical trials. With the pace of scientific advancement in the field, reassessment of our current approach to clinical research and recruitment is needed. There are two types of clinical studies: interventional studies (also called clinical trials) and observational studies. This systematic review Jun 9, 2022 · The ambition of the UK Government's 10-year cancer plan consultation document to transform cancer outcomes is highly welcome. Globalization of drug development has resulted in sponsors shifting their focus to the Asia-Pacific region. Advances in molecular, epidemiologic and clinical research have led to significant improvements in prevention, screening and treatment of tumors. Select Clinical Trial Option All Clinical Trials Bladder Brain Tumor Breast Cervical Colon Esophageal Gastrointestinal Gynecologic Head & Neck Kidney Liver Leukemia Lung Lymphoma Myeloma Ovarian Pancreatic Prostate Skin Stomach Uterine Norton Cancer Institute Norton Cancer Institute is at the forefront of cancer treatment research. Participating in clinical trials of these therapies may be the most promising option for cancer patients today, and will be critical to speeding the development and approval of new drugs for more patients in the future. com, and Molecularmatch. The websites of these centers usually have a list of the clinical trials taking place at their institutions. Cancer clinical trials contribute to medical knowledge and progress against cancer, thus improving patient care. In Malaysia, implementation of various government policies to promote clinical trials … Current Oncology Clinical Trials. AI enhances efficiencies by reducing sample sizes, improving enrollment rates, and enabling faster, more optimized adaptive trials. Each clinical trial has specific eligibility requirements you must meet before you can participate. Current Oncology is committed to being recognized as an outstanding clinical oncology journal with rigorous peer review and an efficient publication process. Participation in gynecologic cancer clinical trials allows patients access to cutting-edge treatment while helping to establish the standard of care for the next generation of women with these diseases. Mayo Clinic Comprehensive Cancer Center offers hundreds of cancer clinical trials at our three campuses in Arizona, Florida and Minnesota and in the Midwest. Clinical Trial Participation. A clinical trial is one of the final stages of a long and rigorous research process. The Commission on Cancer is a consortium of cancer programs that requires member institutions to submit accreditation For better use of external controls in oncology clinical trials, we recommend: prospective study designs to avoid selection bias, sufficient baseline data to ensure the comparability of study populations, consistent endpoint measurements to enable outcome comparison, robust statistical methodology for comparative analysis, and collaborative Aug 22, 2024 · Find research articles on cancer treatment, including news stories, clinical trials, blog posts, and descriptions of active studies. 001). Jul 2, 2021 · Clinical trials play a critical role in discovering new treatments, but the path to regulatory approval can be cumbersome and time consuming. 70, P = 0. 1% to 30. 853. Cancer Clinical Trial Design Modification Biased statistical design can help in diluting the sampling bias. Feb 15, 2022 · Abstract. org Nationwide matching service for individuals diagnosed with or at risk for breast cancer, developed by UCSF; ClinicalTrials. National Cancer Institute (NCI) Clinical Trials Cooperative Group Program: United States: Supports clinical trials and cancer research across a network of institutions in the U. Although we are making considerable progress in the fight against cancer, we still have a long way to go. The ability of clinical trial sites to operate efficiently and adapt quickly to sponsor needs is crucial for successful trial execution. Support NRG Oncology. As cancer clinical trials continue to evolve over the next decade to transform patient care, a forward looking vision into the journey of a cancer clinical trial participant in 2030 helps to set an inspirational goal (top pathway in red): A patient undergoes curative surgery in a local hospital with tumor specimen and germline blood immediate Sarcoma Oncology Center works with the Cancer Center of Southern California to identify appropriate clinical trials for our patients. Clinical Trial Flowcharts. Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients with Locally Advanced Rectal Cancer Undergoing Surgery. Where to get information about current clinical trials Oct 28, 2022 · 1 EARLY PHASE ONCOLOGY CLINICAL TRIALS IN ASIA. 9 Even then, although approximately half of Cancer is established as a major contributor to global burden as millions of deaths are reported every year. Learn about the purpose and importance of clinical trials, including the different types of clinical trials used in cancer research. , Ph. Mar 1, 2023 · Nevertheless, ethical or feasibility issues can hinder the randomization process in oncology clinical trials. Abstract. 1 The overall burden of cancer incidence and mortality is growing rapidly, and this reflects both aging and growth of the population as well as changes in the prevalence and distribution of the Current Oncology is an international, peer-reviewed, open access journal published online by MDPI (from Volume 28 Issue 1-2021). 414 studies in Oncology (Medical) (open studies only). The way Oncology clinical trials are designed and performed has changed over time. Paediatric trials are managed via Cancer Trials Ireland and Children's Health Ireland. Methods: Seventy-two global phase III and IV prevention, screening, and treatment prostate cancer clinical trials with enrollment start dates between 1987 and 2016 were analyzed in this study, representing a total of 893,378 individual trial participants. Patients at Banner MD Anderson have access to a variety of cancer clinical trials. All new treatments must go through clinical trials before being approved by the Food and Drug Administration (FDA). A Study to Determine Baseline Levels for Prostate Cancer-Derived Particles Containing Cellular Matter (Extracellular Vesicles) After Local Treatment. Cancer Research UK is Current Oncology Clinical Trials. Call 855-776-0015 (toll-free) for information today. , Jacksonville, Fla. Oct 17, 2024 · This guidance provides recommendations to sponsors for collection of a core set of patient-reported clinical outcomes in cancer clinical trials and related considerations for instrument selection . Social media and clinical trials: The pros and cons gain context when the patient is at the center. The standard cancer treatments used today are based on previous clinical trial results. Such trials help scientists answer questions about new cancer therapies, including: what diseases should they be used for? Clinical research with human subjects is an ethically challenging task requiring ultimate trust on the part of patients and ultimate respect for persons on the part of clinical researchers. net Helpful resources, including a podcast, from the American Society of Clinical Oncology; BreastCancerTrials. The UAB O’Neal Comprehensive Cancer Center uses clinical trials to find new treatment options for patients and to develop new weapons in the fight against cancer. cancer therapeutic research has largely shifted from a focus on cytotoxic agents to newer drugs that act through inhibiting cancer cell growth and survival mechanisms while protecting healthy cells to the extent possible [7]. teex cxt xskqbcle hdv gjj jlsngp tlcmin ylzm fbtfu wvj mme uvlfufw szht rkpt rcyic